Pharmaceutical Formulation: This book is written by Geoffrey D Tovey. You can download it freely in pdf format. The formulation is a key step in the drug design process, where the active drug is combined with other substances that maximize the therapeutic potential, safety, and stability of the final product. Modern formulation science deals with both biologics and small molecules. Regulatory and quality demands, in addition to advances in processing technologies, result in increasing challenges and possibilities for the field.
Pharmaceutical Formulation provides an up-to-date source of information for all who wish to understand the principles and practice of formulation in the pharmaceutical industry. The book provides an understanding of the links between formulation theory and the practicalities of processing in a commercial setting, giving researchers the knowledge to produce effective pharmaceuticals that can be approved and manufactured. The first few chapters introduce readers to different dosage forms, including oral liquid products, topical products, and solid dosage forms such as tablets and capsules. Later chapters cover pharmaceutical coatings and controlled-release drug delivery. The final chapter provides an introduction to the vital role that intellectual property plays in drug development.
Covering modern processing methods and recent changes in industry quality and regulatory demands, Pharmaceutical Formulation is an essential, up-to-date resource for students and researchers working in academia and the pharmaceutical industry.
|Book Name||Pharmaceutical Formulation|
|Author of Book||Geoffrey D Tovey|
Overview of Pharmaceutical Formulation Pdf FreeAccording to Geoffrey D Tovey, A pharmaceutical formulation is made up of various formulation factors and process variables. Quantitative model-based pharmaceutical formulation involves establishing mathematical relationships between formulation variables and resulting responses and optimizing formulation conditions. In a formulation system involving several targets, the formulation conditions desirable for one property may not always be desirable for other features, leading to the problem of conflicting targets. Therefore, efficient modeling and optimization techniques are needed to design an optimal formulation system.
Ibric and colleagues published their study report on the modeling and optimization of extended-release aspirin tablets with Eudragit L100 as the parent substance and to optimize the formulation by ANN. As model formulations, they prepared 10 different types of aspirin matrix tablets and selected the amount of Eudragit L100 and compression pressure as causal factors. As answers, four different sampling times were chosen from the in vitro dissolution time profiles. To train the generalized regression neural network (GRNN), a set of release parameters and causal factors were used as tutorial data and analyzed by a computer. From the results of drug release studies, they found that drug release rates vary widely among the formulations investigated, ranging from 5 h to more than 10 h for complete dissolution. The GRNN model was optimized by training. They found that the root means square of the trained network was 1.12%, indicating that the optimal GRNN model had been reached. Applying the generalized distance function method, GRNN predicted the optimal tablet formulation. The calculated difference (f1 2.465) and similarity (f2 85.61) factors indicated that there was no difference between the predicted and experimentally observed drug release profiles for the optimal formulation. Their work illustrates the potential for an ANN, GRNN, to aid in the development of extended-release dosage forms.
Topics of this EditionPreformulation Studies
Hard Capsules in Modern Drug Delivery
Suspension Quality by Design
Excipients: Kano Analysis and Quality by Design
Film Coating of Tablets
Oral Controlled Release Technology and Development Strategy
Less Common Dosage Forms
Paediatric Pharmaceutics—The Science of Formulating Medicines for Children
The Formulation of Biological Molecules
About the AuthorGeoffrey D Tovey
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