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HPLC for Pharmaceutical Scientists 1st Edition PDF Free Download

The book HPLC for Pharmaceutical Scientists is written by Yuri V. Kazakevich, and Rosario LoBrutto. This book clarifies the role of HPLC throughout the drug development process, from the inception of the drug candidate to the marketed drug product, and provides specific details of the application of HPLC at each stage of drug development. The latest developments and trends in scripted and specialized HPLC techniques (LC-MS, LC-NMR, preparative HPLC, high-temperature HPLC, and high-pressure liquid chromatography) are also discussed.

In the modern pharmaceutical industry, HPLC is an important analytical tool that is applied at all stages of drug discovery, development, and production. Rapid and effective development of robust analytical HPLC methods is most efficiently carried out with a thorough understanding of HPLC principles, theory, and instrumentation. The primary focus of this book is the reversed-phase analysis of small molecules, although some attention is given to protein LC-MS, LC-NMR, ion exchange, size exclusion, and normal phase chromatography.

 

 

Topics of this Edition

 

PART I HPLC THEORY AND PRACTICE
1 Introduction
2 HPLC Theory
3 Stationary Phases
4 Reversed-Phase HPLC
5 Normal-Phase HPLC
6 Size-Exclusion Chromatography
7 LC/MS: Theory, Instrumentation, and Applications to Small
Molecules
8 Method Development
9 Method Validation
10 Computer-Assisted HPLC and Knowledge Management

PART II HPLC IN THE PHARMACEUTICAL INDUSTRY
11 The Expanding Role of HPLC in Drug Discovery
12 Role of HPLC in Preformulation
13 The Role of Liquid Chromatography–Mass Spectrometry in
Pharmacokinetics and Drug Metabolism
14 Role of HPLC in Process Development
15 Role of HPLC During Formulation Development
16 The Role of HPLC in Technical Transfer and Manufacturing

PART III HYPHENATED TECHNIQUES AND SPECIALIZED
HPLC SEPARATIONS
17 Development of Fast HPLC Methods
18 Temperature as a Variable in Pharmaceutical Applications
19 LC/MS Analysis of Proteins and Peptides in Drug Discovery
20 LC-NMR Overview and Pharmaceutical Applications
21 Trends in Preparative HPLC
22 Chiral Separations

 

 

Overview of HPLC for Pharmaceutical Scientists

HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who routinely use HPLC as an analytical tool to solve complex problems in the pharmaceutical industry. Provides a unified approach to HPLC with fair and balanced treatment of HPLC theory and practice in the pharmaceutical industry.
The in-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases, and columns combine well with the practicalities of developing and validating fast and effective methods. Practical and pragmatic approaches and real examples of the efficient development of selective and robust HPLC methods from a physical-chemical point of view are provided.

This book clarifies the role of HPLC throughout the drug development process, from the inception of the drug candidate to the marketed drug product, and provides specific details of the application of HPLC at each stage of drug development.

The latest developments and trends in scripted and specialized HPLC techniques (LC-MS, LC-NMR, preparative HPLC, high-temperature HPLC, and high-pressure liquid chromatography) are also discussed.

 

Description:

Book Name HPLC for Pharmaceutical Scientists
Author of Book Yuri V. Kazakevich, Rosario LoBrutto
Edition 1st
Language English
Format PDF
Category Pharma Books

 

 

HPLC for Pharmaceutical Scientists

 

 

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